Mairead McGuinness has consistently been a prominent advocate for Ireland on the European stage. Her contributions span a wide spectrum of Irish and broader European society, making her a respected figure, especially in the context of the influential role she played in the Brexit process. As a dynamic leader within the European Parliament, she stood out, particularly as a strong advocate for women, and is well-regarded for her fair and decisive approach in steering parliamentary discussions.

Her journey in the European Parliament began in 2004, and over the years, she has climbed the ranks, first as Vice-President in 2014 and then assuming the role of First Vice-President in January 2017. In her capacity as First Vice-President, she plays a vital role in overseeing interactions with national parliaments, especially the EU affairs committees of Member State parliaments. Additionally, she shoulders the responsibility of nurturing the Parliament's engagements with both religious and non-confessional organizations concerning EU policies and legislative proposals. Since 2020, She is serving as the European Commissioner for Financial Stability, Financial Services and the Capital Markets Union.

Prior to her work in the European institutions, she was an award-winning journalist, broadcaster and commentator.